1 Year of COMBINE: Laying the Foundations for Understanding Viral Entry
One year into the project, we have successfully laid strong scientific and collaborative foundations to advance our understanding of how viruses enter host cells. Using the Marburg virus (MARV) as a model, COMBINE focuses on the earliest and most critical step of viral infection: virus–cell attachment and entry. By identifying the host factors and molecular mechanisms involved at this stage, we aim to develop new pipelines for antiviral strategies and pandemic preparedness.
COMBINE has built a solid project framework by establishing robust management structures, a dedicated communication strategy, and a scientific advisory board. The project has already achieved substantial scientific progress across its work packages, including the development of new model systems and analytical assays that were implemented in a coordinated manner across multiple sites in Europe.
“Over the past year, we have built a strong and highly collaborative network across European laboratories, united by the joint goal of developing new tools and establishing robust experimental pipelines for the rapid investigation of emerging viral pathogens. In the second year, we will begin to deploy these newly established platforms to address key questions in the biology of MARV infection. I am proud of what we have achieved in the first year and excited about the discoveries and progress the next 12 months will bring,” Christian Sieben, COMBINE coordinator.
As we move into our next project year, the consortium looks forward to delivering new scientific insights, strengthening international collaboration, and contributing to global pandemic preparedness.